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However, important limitations remain

PubMed PMID:18670730

Future research should emphasize standardized experimental protocols, mechanistic clarification of AMPK signaling, and large-scale randomized trials to establish whether metformin can reliably protect the human heart during anthracycline chemotherapy

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doi: 10.3389/fcell.2022.841831 Received 22 December 2021 Accepted 09 February 2022 Published 11 March 2022 Volume 10 - 2022 Edited by Chisa Shukunami, Hiroshima University, Japan Reviewed by Petra Kraus, Clarkson University, United States Danny Chan, The University of Hong Kong, Hong Kong SAR, China Updates Copyright 2022 Hickman, Rathan-Kumar and Peck